目的:探讨硝苯地平缓释片联合美托洛尔治疗高血压的临床观察及疗效。方法:将116例高血压病患者随机分为2组。治疗组58例,给予硝苯地平缓释片10mg,2次/d,美托洛尔25mg,2次/d。对照组58例,单给硝苯地平缓释片20mg,1次/d。疗程均为8周。结果:治疗组降压的效果、心率下降和血压平均下降幅度均大于对照组,(P<0.01)。结论:硝苯地平缓释片联合美托洛尔的降压效果显着,不良反应少。 Objective: To investigate the clinical observation and curative effect of nifedipine sustained-release tablets combined with metoprolol in the treatment of hypertension. Methods: 116 cases of hypertension were randomly divided into two groups. Treatment group of 58 patients were given nifedipine sustained-release tablets 10mg, 2 times / d, metoprolol 25mg, 2 times / d. Control group of 58 patients were given single nifedipine sustained-release tablets 20mg, 1 time / d. The course of treatment is 8 weeks. Results: The effect of antihypertensive treatment, heart rate reduction and mean decrease of blood pressure in the treatment group were greater than those in the control group (P <0.01). Conclusion: Nifedipine sustained-release tablets combined with metoprolol have significant antihypertensive effect and few adverse reactions.