先天性多发性关节挛缩(Arthrogryposis multiplex congenita)被认为是一种特殊的临床疾患.累及孪生者罕见,Lipton(1955)报告一对孪生兄弟同患此病,国内尚未见孪生者同患此病的报导.现将我们遇到的一对孪生姊妹同时患病,报告如下.例1.女,16岁(为例2孪生姐姐).自出生即见四肢肌肉萎缩,多个关节屈曲挛缩、僵硬和活动受限.16年来病情无进行性加重.月经来潮,周期正常.无家族因素,生产史无特殊.3岁时曾患膀胱结石手术. Arthrogryposis multiplex congenita is considered to be a special clinical condition.It is uncommon for twins to be involved, and Lipton (1955) reported that a twin brother was suffering from the same disease Reported the same time we encountered a twin sisters at the same time, reported as follows.Example 1. Female, 16 years old (for example, 2 twin sister) from birth to see limb muscle atrophy, multiple joint flexion contracture, stiffness and Activity was limited .16 years without progressive aggravating conditions.Menstrual cramps, normal cycle.Familiar factors, no special history of production .3 years old had bladder stone surgery.