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慢性支气管炎和肺气肿是慢性阻塞性肺疾病的二个主要疾病。从人肺和实验性肺气肿研究已经明确肺气肿由于肺弹性的减退和肺泡壁到细支气管上皮的破坏而引起气道阻力增加。研究人肺功能和结构的相互关系,提示中央气道的改变对气道阻塞作用不大,而小气道损害是主要原因,本文将集中国内外实验研究结果,理解气道对损害的反应和气管、细支气管的病理改变之间的关系。
Chronic bronchitis and emphysema are the two major diseases of chronic obstructive pulmonary disease. From studies of human lungs and experimental emphysema, it has been clarified that emphysema causes increased airway resistance due to decreased lung elasticity and destruction of alveolar walls to bronchiolar epithelium. To study the relationship between human lung function and structure, suggesting that central airway changes have little effect on airway obstruction, and small airway damage is the main reason. This article will focus on the results of domestic and foreign experimental studies to understand the airway response to injury and trachea Relationship between pathological changes in bronchioles.