根据报导:5—羟色胺(5—HT)对肾上腺摘除大鼠和小鼠的毒性比对肾上腺未摘除的动物大很多倍,为了探讨其毒性增强的机制,作者曾进行了若干药理和生化的实验,发现给肾上腺摘除大鼠静脉注射5—HT3.75mg/kg 后所致降低体温的作用,相当于给未摘除肾上腺大鼠静脉75mg/kg 所产生的作用;又5—HT 对肾上腺摘除大鼠所引起的降压作用,比 It has been reported that the toxicity of 5-hydroxytryptamine (5-HT) to adrenocortical rats and mice is many times greater than that of animals not removed from the adrenal gland. To investigate the mechanism of its toxicity enhancement, the authors conducted several pharmacological and biochemical experiments , Found that adrenal ablation rats intravenously injected 5-HT3.75mg / kg caused by the role of reducing body temperature, equivalent to the non-removed adrenal vein 75mg / kg produced by the role; 5-HT adrenal ablation rats Caused by the antihypertensive effect, than