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目的 评价C_3、C_4在HCC患者中的诊断价值,监测意义及解释其有关机制。方法 分四组,对照组25例,病例组27例,肝硬化组15例,肝炎组15例,检验、分析、比较各组的C_3、C_4水平,病例组中一些可能影响C_3、C_4水平的因素被分析,同时运用免疫组化方法,以解释C_3、C_4升高的机制。结果 病例组中,C_3、C_4水平显著高于对照组、肝硬化组和肝炎组,以对照组中±s为截断点,则C_3、C_4的敏感性、特异性、准确性分别为:C_344.4％、92％、78.8％及67.3％、81％、73％。AFP与之联合诊断阳性率分别为85％及89％,而特异性并无明显降低.结论 监测C_3、C_4有助于HCC的诊断,C_3于HCC患者中升高机制为癌肿产生C_3及CINH升高;C_4升高机制为CINH升高,并与癌肿本身关系密切,后者有待进一步研究。
Objective To evaluate the diagnostic value of C_3 and C_4 in patients with HCC, monitor its significance and explain its related mechanisms. The methods were divided into four groups: 25 in the control group, 27 in the case group, 15 in the cirrhosis group, and 15 in the hepatitis group. The levels of C 3 and C 4 in each group were examined, analyzed and compared. Some of the cases may affect the levels of C 3 and C 4 Factors were analyzed and immunohistochemical methods were used to explain the mechanism of C3 and C4 elevation. Results In the case group, the levels of C_3 and C_4 were significantly higher than those in the control group, cirrhosis group, and hepatitis group. In the control group, ±s was the cut-off point. The sensitivity, specificity, and accuracy of C_3 and C_4 were: C_344. 4%, 92%, 78.8%, and 67.3%, 81%, and 73%. The positive rate of combined AFP diagnosis was 85% and 89%, respectively, while the specificity was not significantly reduced. Conclusion Monitoring C_3, C_4 is helpful for the diagnosis of HCC, C_3 mechanism for the increase of cancer in patients with HCC C_3 and CINH Elevated; C_4 elevation mechanism is elevated CINH, and closely related to the cancer itself, which needs further study.