信号转导和转录激活因子3(STAT3)是细胞内关键性的信号转导蛋白,在肿瘤细胞的增殖、去分化以及肿瘤的侵袭、转移中起重要作用。研究发现,在胰腺癌、乳腺癌、肺癌、前列腺癌、宫颈癌等肿瘤中均有STAT3的异常表达。现就STAT3蛋白的生物学特性、与肿瘤的关系及其在宫颈癌中的研究现状予以综述。 Signal Transducer and Activator of Transcription 3 (STAT3) is a key intracellular signaling protein that plays an important role in tumor cell proliferation, dedifferentiation and tumor invasion and metastasis. The study found that in pancreatic cancer, breast cancer, lung cancer, prostate cancer, cervical cancer and other tumors have abnormal STAT3 expression. The biological characteristics of STAT3 protein, the relationship with the tumor and its status in cervical cancer are reviewed.