论文部分内容阅读
目的研究福建地区Barrett食管(BE)的发病情况和内镜、临床特点及其与反流性食管炎(RE)的关系。方法根据新标准诊断BE,研究BE患者的内镜下检出率、内镜表现、分型及病理检查结果,分析患者的年龄、性别、症状、幽门螺杆菌(Hp)感染情况及其与RE的关系。结果检出BE为总胃镜检查人数的7.90%,男女之比为1.98,平均年龄(45.1±14.8)岁,仅19.15%有典型反流症状。BE中短节段占81.20%,多为舌状、岛状或包含这2种形状的混合型。食管活检组织病理诊断为肠化型占BE的34.83%,9.88%伴异型增生,胃窦Hp阳性率为39.94%。RE检出率为2.07%,比BE显著降低(P<0.01)。8.42%的BE伴RE,32.11%的RE伴BE。结论福建地区BE患病率较高,多为短节段舌状或岛状,约1/3为肠化型,以中年男性多见,常无症状,与RE无明显相关性,部分伴异型增生。BE的临床意义和预后有待于进一步研究。
Objective To study the incidence, endoscopic features and clinical features of Barrett’s esophagus (BE) in Fujian Province and its relationship with reflux esophagitis (RE). Methods Based on the new criteria of BE, we investigated the endoscopic detection rate, endoscopic findings, classification and pathological findings of patients with BE, and analyzed the age, gender, symptoms, H. pylori infection and their relationship with RE Relationship. Results BE was 7.90% of the total number of gastroscopy, the ratio of male to female was 1.98, mean age (45.1 ± 14.8) years old, only 19.15% had typical reflux symptoms. BE segments accounted for 81.20% of short segments, mostly tongue, island or a mixture of these two forms. Esophageal biopsy was diagnosed as intestinal metaplasia accounting for 34.83% of BE, 9.88% with dysplasia, gastric antrum Hp positive rate was 39.94%. The detection rate of RE was 2.07%, which was significantly lower than that of BE (P <0.01). 8.42% BE with RE, 32.11% RE with BE. Conclusions The prevalence rate of BE in Fujian area is high, most of which are short segments of tongue or island, about 1/3 of which are intestinal metaplasia, more common in middle-aged men and often asymptomatic, with no significant correlation with RE and some with Abnormal hyperplasia. The clinical significance and prognosis of BE require further study.