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目的:探讨妊娠高血压患者血清蛋白Z(PZ)与高敏C反应蛋白(hs-CRP)水平检测的临床意义。方法:选择2011年12月到2014年12月我院收治的120例妊娠高血压患者作为实验组,同期选择100例健康产妇作为对照组。检测所有研究对象的血清PZ、hs-CRP水平,分析比较不同血压、妊娠期下各组间血清PZ与hs-CRP的差别。结果:不同程度高血压组妊娠患者血清PZ、hs-CRP水平差异具有显著性(P<0.05),随高血压程度加重,PZ水平下降、hs-CRP水平升高。实验组血清PZ水平随妊娠期发展逐渐下降,且不同妊娠期血清PZ水平均明显低于对照组(P<0.05)。实验组血清hs-CRP水平随妊娠期发展逐渐上升,且不同妊娠期血清hs-CRP水平均明显高于对照组(P<0.05)。结论:血清PZ水平降低和hs-CRP水平升高会导致孕妇血压升高,检测孕妇血清PZ与hs-CRP对预防和治疗妊娠高血压具有一定的临床意义。
Objective: To investigate the clinical significance of detecting serum protein Z (PZ) and high-sensitivity C-reactive protein (hs-CRP) in patients with pregnancy-induced hypertension. Methods: 120 cases of pregnancy-induced hypertension in our hospital from December 2011 to December 2014 were selected as experimental group and 100 healthy maternal women as control group. All subjects were tested for serum PZ, hs-CRP levels, analysis of different blood pressure, pregnancy, serum PZ and hs-CRP differences between groups. Results: The levels of serum PZ and hs-CRP were significantly different in hypertensive patients with different degrees of hypertension (P <0.05). The level of PZ decreased and the level of hs-CRP increased with the severity of hypertension. The level of serum PZ in experimental group decreased gradually with the development of pregnancy, and serum PZ levels in different pregnancy groups were significantly lower than those in control group (P <0.05). The level of hs-CRP in experimental group increased gradually with the development of pregnancy, and the levels of serum hs-CRP in different pregnancy groups were significantly higher than those in control group (P <0.05). Conclusion: The decrease of serum PZ level and the increase of hs-CRP level lead to the increase of blood pressure in pregnant women. It is of clinical significance to detect serum PZ and hs-CRP levels in pregnant women for the prevention and treatment of pregnancy-induced hypertension.