恶性黑色素瘤来源于成黑色素细胞、好发于皮肤。口腔内的恶性黑色素瘤多见于牙龈和腭部,来自粘膜黑斑和色素痣;约有30％的粘膜黑斑可发生恶变。临床特点是肿瘤呈蓝黑色,为扁平结节状或乳突状的肿块,生长迅速,向四周扩散,并浸润至粘膜及骨组织内引起牙槽突及颌骨破坏,使牙齿发生松动,故典型的恶性黑色素瘤不难诊断。但无色素性恶性黑色素瘤甚少 Malignant melanoma originates from melanocytes and prevails in the skin. Malignant melanoma in the oral cavity is more common in gingiva and gingivae, from the mucosal dark spots and pigmented nevi; about 30% of the mucosal dark spots can be malignant. The clinical feature is that the tumor is blue-black, with a flat nodular or papillary mass that grows rapidly, spreads around, and infiltrates into the mucous membranes and bone tissue to cause destruction of the alveolar processes and jaws, causing loosening of the teeth. Typical malignant melanomas are not difficult to diagnose. However, few pigmented malignant melanomas