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目的探讨肝纤维肝硬化定量诊断的无创、简便、有综合判断价值的量化指标,为肝纤维化、肝硬化的病情判断和疗效考核提供客观依据。方法将30只雄性新西兰白兔随机分为空白组、模型组,每组各15只,模型组采用精制橄榄油配制成40%CCl4,1.5ml/kg,灌胃,1次/周造模,于造模前及造模后2、4、6个月分别观察凝血酶原时间、白蛋白、B超等22项指标,并以病理结果为对照,采用统计软件SPSS10.0进行统计分析,建立回归方程。结果建立各期的判别函数式分别为:Z1(正常)、Z2(肝纤维化期)、Z3(肝硬化代偿期)、Z4(肝硬化失代偿期)。应用时将新例观测值代入上述四个判别函数中,哪一个值最大就判为哪一类。结论回代检验中实际情况与判别结果的符合率为98.3%,判别能力具有高度统计意义。
Objective To investigate the quantitative indexes of quantitative diagnosis of liver cirrhosis with noninvasive, simple and comprehensive judgments, and to provide an objective basis for judging the condition of liver fibrosis and cirrhosis and evaluating the curative effect. Methods Thirty male New Zealand white rabbits were randomly divided into blank group and model group with 15 rats in each group. The model group was made of refined olive oil (40% CCl4, 1.5ml / kg) The indexes of prothrombin time, albumin and B-ultrasonography were observed before modeling and 2, 4, and 6 months after modeling respectively. The pathological results were used as a control, and the statistical software SPSS10.0 was used for statistical analysis to establish the regression equation. Results The discriminant functions of each stage were: Z1 (normal), Z2 (liver fibrosis), Z3 (liver cirrhosis decompensation), Z4 (liver cirrhosis decompensation). Application of the new case of the observed value into the above four discriminant function, which one is the largest sentence for which category. Conclusion The coincidence rate between the actual situation and the discriminant result in the back-substitution test is 98.3%, and the discriminatory ability is highly statistically significant.