阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。随机对照试验显示,在OSA患者中,持续气道正压通气(continuous positive airway pressure,CPAP)可使正常血压患者血压 Obstructive sleep apnea (OSA) causes paroxysmal hypoxemia, nocturnal sympathetic nervous system activation, elevated blood pressure, oxidative stress and inflammation, and hypercoagulability. Larger intrathoracic negative pressure fluctuations also apply mechanical stress to the heart and blood vessels. Cohort studies based on population and sleep clinics have shown that OSA is associated with cardiovascular and cerebrovascular events, particularly stroke. Randomized controlled trials have shown that continuous positive airway pressure (CPAP) in patients with OSA can make normotensive blood pressure