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本文采用高效液相法（ＨＰＬＣ）测定了卡马西平的血药浓度，在１８只家兔体内观察不同剂量下药物浓度变化和药动学参数差异。结果发现家兔在两种剂量下均有双峰现象，这一现象估计与肠－肝循环有关，两组剂量的Ｔ１／２间有显著差异，高剂量组的平均Ｔ１／２比低剂量的下降一半。这一结论应引起临床医师的注意
In this paper, high-performance liquid chromatography (HPLC) was used to determine the plasma concentration of carbamazepine in 18 rabbits in vivo observation of different doses of drug concentration changes and differences in pharmacokinetic parameters. The results showed that there was a bimodal phenomenon in rabbits at both doses. This phenomenon was estimated to be related to the enterohepatic circulation. There was a significant difference between the two groups of T1 / 2 doses. The average T1 / 2 of the high dose group was lower than that of the low dose Drop in half. This conclusion should arouse the attention of clinicians