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在正常个体和145例自身免疫性血小板减少症病人(AITP)中,应用酶联测定系统,除测定与血小板相关的IgG(PAIgG)外,还测定了与血小板相关的IgM(PAIgM),正常个体中 PAIgM的平均水平是 1.17ng/10~6血小板,范围在0.01—2.45ng(X±2SD)。相应的PAIgG值如下,均数为6.0ng:范围在2.0—10ng/10~6血小板。67.6％的病人可看到PAIgG的升高,79.3％的病人有异常升高的PAIgM,两种值都升高占57.2％,89.7％病人有PAIgG升高或PAIgM升高。在所有的病人中,PAIgG值比异常的PAIgM值上限高4倍以上。本文讨论了在自身免疫性血小板减少症病人中,PAIgM升高的因素,PAIgG与PAIgM间可能的相互影响以及我们的试验结果。
In normal individuals and 145 patients with autoimmune thrombocytopenia (AITP), enzyme-linked assay system was used to determine platelet-associated IgM (PAIgG) in addition to platelet-associated IgG (PAIgG), normal individuals The average level of PAIgM was 1.17 ng / 10 to 6 platelets, ranging from 0.01 to 2.45 ng (X ± 2 SD). The corresponding PAIgG values are as follows, with a mean of 6.0 ng: ranging from 2.0 to 10 ng / 10 to 6 platelets. Elevated PAIgG was seen in 67.6% of patients, PAIgM was abnormally elevated in 79.3% of patients, 57.2% of both values were elevated, and 89.7% of patients had elevated PAIgG or elevated PAIgM. In all patients, the PAIgG value was more than four times higher than the abnormal upper limit of PAIgM value. This article discusses the factors that increase PAIgM in patients with autoimmune thrombocytopenia, the possible interactions between PAIgG and PAIgM, and our results.