论文部分内容阅读
吡喹酮是1975年由西德拜耳和怡默克药厂合成,最初用来治疗绦虫病。以后经动物实验证明有强大的杀血吸虫作用。1977年联合国卫生组织推荐为最有希望的抗血吸虫病新药。国内上海、南京和武汉已相继合成。一、理化性质化学名为2—环乙羰基—1,3,4,6,11b—六氢—2 H—吡嗪并—[2,1,a]—异喹啉—4—酮。分子式为C_(19)H_(24)·N_2O_2,分子量为312.42,是无色,无臭,微苦的结晶粉末。不溶于
Praziquantel was synthesized by West Bayer and Prohm Pharma in 1975 and was originally used to treat taeniasis. After animal experiments proved a strong kill schistosome effect. In 1977 the United Nations recommended by WHO as the most promising new anti-schistosomiasis medicine. Domestic Shanghai, Nanjing and Wuhan have been synthesized. First, the physical and chemical properties Chemical name is 2-cyclohexylcarbonyl-1,3,4,6,11b-hexahydro-2H-pyrazino- [2,1, a] -isoquinolin-4-one. Molecular formula is C_ (19) H_ (24) N_2O_2, molecular weight of 312.42, is colorless, odorless, slightly bitter crystalline powder. Insoluble in