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人宫颈癌与人乳头瘤病毒(HPV)的关系是当今国际重视的研究课题之一。在我国有关研究鲜有报道。本文在国内五个地区(新疆、北京、湖北、黑龙江,贵州)共获得经病理学确诊的人宫颈鳞状上皮癌318例,宫颈上皮内新生物(CIN)14例,宫颈及外阴湿疣48例,慢性宫颈类34例及正常宫颈上皮组织24例。将上述组织提取DNA后,以~(32)p标记的HPV-11,16,18三型病毒DNA为探针与上述组织进行核酸杂交,其中32例宫颈癌10例正常宫颈及27例宫颈及外阴湿疣还进行平行的电子显微镜对比研
The relationship between human cervical cancer and human papillomavirus (HPV) is one of the most important international research topics nowadays. Little research has been reported in our country. In this study, 318 pathologically diagnosed squamous cell carcinomas of the cervix, 14 cervical intraepithelial neoplasms (CINs), 48 cervical and genital warts (48 cases) were obtained from five regions in China (Xinjiang, Beijing, Hubei, Heilongjiang and Guizhou) 34 cases of chronic cervix and 24 cases of normal cervical epithelium. After extracting the DNA from the above tissues, nucleic acid hybridization was performed with the ~ (32) p-tagged HPV-11, 16,18 type III viral DNA and the above tissues. Of the 32 cervical cancer cases, 10 cases were normal cervix and 27 cases were cervical and Genital wet warts also conducted parallel electron microscopy contrast study