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目的探讨消栓口服液在主动脉球囊扩张损伤后对血管壁细胞的影响。方法新西兰雄性兔２０只均施行主动脉球囊扩张术，消栓口服液灌服２．５ｍｌ／ｋｇ，每周６次。结果①术后主动脉内膜厚度和平滑肌细胞的３Ｈ－脱氧胸苷掺入率，用药组明显低于对照组（Ｐ＜０．０５）．②术后主动脉内皮血小板源生长因子受体ｍＲＮＡ表达的组间比较，显示用药组有明显的抑制作用（Ｐ＜０．０５）。结论消栓口服液可抑制主动脉球囊扩张术后血管壁的病理增生和具有减轻术后主动脉再狭窄的作用。
Objective To investigate the effect of Xiaoshuan oral liquid on vascular wall cells after balloon injury of aorta. Methods 20 New Zealand male rabbits underwent aortic balloon dilation, and Xiaoshu oral liquid was given 2.5 ml/kg every 6 times a week. Results 1Aortic intima thickness and 3H-deoxythymidine incorporation rate in smooth muscle cells were significantly lower in the drug group than in the control group (P<0.05). 2 Comparison of platelet-derived growth factor receptor mRNA expression in aortic endothelium after surgery showed that the drug group had a significant inhibitory effect (P<0.05). Conclusion Xiaoshuan Oral Liquid can inhibit the pathological hyperplasia of blood vessel wall after aortic balloon dilatation and has the effect of reducing postoperative aortic restenosis.