论文部分内容阅读
目的探讨他汀联合贝前列腺素钠片治疗下肢动脉硬化闭塞症(Fontaine分期Ⅰ~Ⅲ期)的疗效及安全性。方法选取下肢动脉硬化闭塞症患者396例,予他汀联合贝前列腺素钠片治疗12周,观察治疗前后踝肱指数,下肢动脉血管内径、血流量、血流峰时速度及实验室指标(血纤维蛋白原及血流变学指标,血脂及载脂蛋白指标)。结果治疗前和治疗后12周,患肢踝肱指数差异无统计学意义(P>0.05);治疗后下肢动脉的直径、峰值流速及逆向平均流速均有显著改善(p<0.05);治疗后纤维蛋白原及全血黏度、血浆黏度较治疗前均有明显降低(P<0.05);治疗后总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)以及甘油三酯(TG)较治疗前明显下降(P<0.05),而高密度脂蛋白胆固醇(HDL-C)水平则明显提高(P<0.05)。结论他汀联合贝前列腺素钠治疗下肢动脉硬化闭塞症是一种安全有效的方法 。
Objective To investigate the efficacy and safety of statins combined with beraprost sodium in the treatment of lower extremity arteriosclerotic occlusive disease (Fontaine staging Ⅰ ~ Ⅲ). Methods 396 patients with atherosclerotic occlusive disease of the lower extremities were selected and treated with statins and beraprost sodium tablets for 12 weeks. The ankle brachial index, arterial blood vessel diameter, blood flow velocity, peak velocity and laboratory indexes (blood fiber Protein and blood rheology indicators, blood lipids and apolipoprotein markers). Results Before treatment and 12 weeks after treatment, there was no significant difference in ankle brachial index between the two groups (P> 0.05). After treatment, the diameter, peak velocity and mean velocity of lower extremity arteries were significantly improved (p <0.05) Fibrinogen, whole blood viscosity and plasma viscosity were significantly lower than those before treatment (P <0.05). After treatment, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and triglyceride (P <0.05), while the level of HDL-C increased significantly (P <0.05). Conclusions Statin and beraprost sodium are safe and effective in the treatment of arteriosclerosis obliterans of lower extremity.