近年,自由基(FR)的概念已深入医学界诸领域,氧自由基(OFR)的危害亦日益受到重视,迄今已有大量文献报道。处于高氧环境中的肺尤易受累,且机理复杂,既可通过脂质过氧化、蛋白质、DNA等直接损伤,还可协同其他炎性介质、蛋白酶等,引发肺血管内皮细胞、气道上皮细胞及肺间质细胞的损伤,可使α-抗胰蛋白酶氧化失活,导致肺血管通透性增加、支气管痉挛、 In recent years, the concept of free radical (FR) has penetrated into various fields of medical science. The harm of oxygen free radical (OFR) has also been paid more and more attention. So far, a large amount of literature has been reported. In hyperoxia environment, the lung is especially vulnerable and its mechanism is complicated. It can not only directly damage lipid peroxidation, protein and DNA, but also cooperate with other inflammatory mediators and proteases to induce pulmonary vascular endothelial cells, airway epithelium Cells and interstitial lung injury, α-antitrypsin can be oxidative inactivation, leading to increased pulmonary vascular permeability, bronchospasm,