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目的:研究女性生殖道高危型人乳头瘤病毒(HR-HPV)检查方法在宫颈病变筛查中的应用价值。方法:收集1001名20～67岁、已婚或有性生活史的体检女性患者的宫颈外口及宫颈管分泌物,采用第二代杂交捕获试验(HC2)进行HPVDNA检测,所有患者均行阴道镜活组织检查。通过随诊对照其细胞学与组织学结果,探讨该技术在宫颈病变筛查中的应用价值。结果:在1001名检查对象中,高危型HPV感染者为216例。非高危型HPV感染者经阴道镜活组织检查,正常者784例(99.87%),异常者为1例(0.13%)。高危型HPV感染者经阴道镜活组织检查,正常者112例(51.85%),异常者为104例(48.15%)。结论:高危型HPVDNA检测是子宫颈疾病筛查的有效手段。
Objective: To study the value of high-risk human papillomavirus (HR-HPV) screening in female genital tract in screening cervical lesions. Methods: A total of 1001 cervical and cervix secretions of female patients aged 20 ~ 67 years with married or sexual life history were collected. The second generation hybridization capture test (HC2) was used to detect HPVDNA. All patients underwent vaginal Mirror biopsy. Through follow-up comparison of its cytology and histological findings, to explore the value of this technology in cervical lesions screening. Results: Of the 1001 subjects, 216 were at high risk of HPV infection. Non-high risk HPV infection by colposcopy biopsy, normal 784 cases (99.87%), abnormal in 1 case (0.13%). High-risk HPV infection by colposcopy biopsy, normal in 112 cases (51.85%), abnormal in 104 cases (48.15%). Conclusion: High-risk HPV DNA detection is an effective method to screen cervical diseases.