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5. Synthesis of 1-aryl-3-(3,4-dihydro-2H-chromen-5-yl)ureas as TNF-α inhibitors

Synthesis of 1-aryl-3-(3,4-dihydro-2H-chromen-5-yl)ureas as TNF-α inhibitors

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：yeyuan1985

【摘 要】

：

A new series of compounds, 1-aryl-3-(3,4-dihydro-2H-chromen-5-yl) ureas, have been synthesized and their structures were confirmed by FAB-MS and 1H NMR. The pre

【作 者】

：

Xin Ming Zhou Zhi Bing Zheng H 

【机 构】

：

School of Pharmaceutical Engineering,Institute of Pharmacology and Toxicology

【出 处】

：

中国化学快报（英文版）

【发表日期】

：

2004年期

【关键词】

：

p38 MAPK inhibitor 1-Aryl-3-(3 4-dihydro-2H-chromen-5-yl) ureas Synthesis 

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论文部分内容阅读

A new series of compounds, 1-aryl-3-(3,4-dihydro-2H-chromen-5-yl) ureas, have been synthesized and their structures were confirmed by FAB-MS and 1H NMR. The preliminary pharmacological screening showed that these compounds inhibited TNF-αproduction in lipopolysaccharide (LPS)-stimulated THP-1 cells.

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