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目的探讨和分析他汀类药物在急性冠状动脉综合征介入术前应用的临床疗效,总结其临床价值。方法回顾性分析具有完整临床资料的2008年10月至2010年10月来我院就诊的急性冠状动脉综合征患者100例,随机分为观察组和对照组两组,每组患者有50例,对照组给予常规介入治疗,观察组在对照组治疗的基础上加用他汀类药物进行治疗,观察和比较两组不同治疗方法对急性冠状动脉综合征的临床疗效。结果两组患者术前C反应蛋白水平差异无统计学意义(P>0.05),术后1d两组的C反应蛋白水平具有显著性差异,随着时间延长,观察组的C反应蛋白的水平下降幅度与对照组相比具有显著性差异,观察组的C反应蛋白的水平下降更为明显。两组患者治疗前血脂水平无显著性差异,治疗后观察组血脂水平明显下降,与对照组相比差异有统计学意义(P<0.05)。结论他汀类药物在急性冠状动脉综合征介入术前应用疗效显著,安全可靠,是治疗急性冠状动脉综合征的有效方法之一,值得临床推广和应用。
Objective To investigate and analyze the clinical efficacy of statins in the preoperative interventional treatment of acute coronary syndrome and to summarize its clinical value. Methods A retrospective analysis of 100 patients with acute coronary syndrome who came to our hospital from October 2008 to October 2010 with complete clinical data was randomly divided into observation group and control group, with 50 patients in each group. The control group was given conventional interventional therapy. The observation group was treated with statins on the basis of the control group. The clinical effects of two different treatment methods on acute coronary syndrome were observed and compared. Results There was no significant difference in preoperative C-reactive protein between the two groups (P> 0.05). The level of C-reactive protein in the two groups was significantly different at 1 day after operation. With the prolongation of time, the level of C-reactive protein in the observation group decreased Significant differences compared with the control group, the observation group decreased C-reactive protein levels even more pronounced. There was no significant difference in blood lipid level between the two groups before treatment. After treatment, the level of blood lipid in the observation group decreased significantly compared with the control group (P <0.05). Conclusion The statin is effective in the treatment of acute coronary syndrome before surgery. It is safe and reliable and is one of the effective methods to treat acute coronary syndrome. It is worthy of clinical promotion and application.