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目的:探讨慢性肾脏疾病患者甲状旁腺激素水平对肾性贫血的影响。方法:以2010年9月-2013年9月收入广东省开平市中心医院收治的慢性肾功能衰竭患者200例为慢性肾功能衰竭组,以同期在广东省开平市中心医院进行体检的健康人50例为对照组,使用酶联免疫定量法检测慢性肾功能衰竭患者和健康人的血清甲状旁腺激素、血红蛋白、血磷、血钙水平,并根据慢性肾功能衰竭的分期,将患者分成慢性肾功能衰竭代偿期组(n=51)、氮质血症期组(n=48)、肾衰竭期组(n=67)及尿毒症期组(n=34),比较四组上述指标的变化。结果:慢性肾衰竭患者中,肾衰竭期及尿毒症期的血红蛋白、血钙与甲状旁腺激素水平呈负相关,血磷与甲状旁腺激素水平呈正相关。结论:慢性肾功能衰竭患者血清中甲状旁腺激素水平升高是引起肾性贫血的主要因素,可通过调节钙磷失调,减轻甲状旁腺激素水平持续增加,起到治疗肾性贫血的作用。
Objective: To investigate the effect of parathyroid hormone levels on renal anemia in patients with chronic kidney disease. Methods: From September 2010 to September 2013, 200 patients with chronic renal failure who were admitted to Kaiping Central Hospital of Guangdong Province were admitted to Kaifeng Central Hospital for chronic renal failure. Cases of control group, the use of enzyme-linked immunosorbent assay in patients with chronic renal failure and healthy people serum parathyroid hormone, hemoglobin, phosphorus, blood calcium levels, and according to the chronic renal failure stage, the patients were divided into chronic kidney (N = 51), azotemia group (n = 48), renal failure group (n = 67) and uremia group (n = 34) Variety. Results: In patients with chronic renal failure, there was a negative correlation between hemoglobin, serum calcium and parathyroid hormone during renal failure and uremia, and serum phosphate and parathyroid hormone levels were positively correlated. Conclusion: The increase of serum parathyroid hormone level in patients with chronic renal failure is the main cause of renal anemia. It may play a role in the treatment of renal anemia by regulating the imbalance of calcium and phosphorus and decreasing the level of parathyroid hormone.