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尿粘康酸是苯代谢产物中的一个极小分支，由于其在体内极低的本底值而受到重视。本研究采用强阴离子交换树脂预处理尿样，用ＨＰＬＣ—ＵＶ检测苯作业工人班前班末尿粘康酸浓度，并与尿酚及个体苯加权平均浓度进行相关分析。研究发现，苯作业工人尿粘康酸与尿酚、苯加权平均浓度三者之间良好相关，尿粘康酸比尿酚具备更好的敏感性与特异性，并能在个体苯加权平均浓度约３．８ｍｇ／ｍ￣３水平区分个体苯接触，尿粘康酸在苯生物监测中前景广阔。
Urinary muconic acid is a very small branch of the benzene metabolite, which is valued for its very low background in the body. In this study, urine samples were pretreated with strong anion exchange resin, and the urinary muconic acid concentrations were measured by HPLC-UV. The correlation analysis was made between the concentration of urinary mucic acid and the mean concentration of benzene and benzene. Study found that benzene workers urinary muconic acid and urinary phenol, benzene weighted average concentration between the three good correlation, urinary muconic than urinary phenol with better sensitivity and specificity, and in the individual benzene weighted average concentration About 3.8mg / m ~ 3 levels distinguish individual benzene exposure, urinary muconic acid in benzene biomonitoring prospects.