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目的观察低分子肝素钠(LMWHNa)联合阿司匹林治疗急性脑梗死的临床疗效。方法选取我院自2008年1月至2011年1月收治的150例急性脑梗死患者,随机分为治疗组(使用低分子肝素钠5000单位皮下注射,2次/d,共7d。阿司匹林100mg,1次/d,共7d。)和对照组(不使用低分子肝素钠和阿司匹林)各75例,比较2组患者的治疗效果。结果①治疗组基本痊愈43例,显效25例,总有效率90.7%;对照组基本痊愈26例,显效29例,总有效率73.3%。2组患者比较差异显著(P<0.01),具有统计学意义。②治疗组与对照组治疗前后神经功能缺损评分均有所改善,但治疗组较对照组改善明显(P<0.01),具有统计学意义。结论低分子肝素钠联合阿司匹林治疗脑梗死在改善偏瘫、失语等神经系统症状以及血凝变化等方面具有一定的疗效,其作用强、起效快、效果好、安全性可靠,在临床治疗中值是得推广应用的。
Objective To observe the clinical effect of low molecular weight heparin (LMWH) combined with aspirin in the treatment of acute cerebral infarction. Methods A total of 150 acute cerebral infarction patients admitted to our hospital from January 2008 to January 2011 were randomly divided into treatment group (subcutaneous injection of low molecular weight heparin 5000 units twice a day for 7 days, aspirin 100 mg, 1 / d, a total of 7d.) And the control group (without the use of low molecular weight heparin and aspirin) in 75 cases, the treatment effect of two groups were compared. Results The treatment group was basically cured in 43 cases, markedly effective in 25 cases, the total effective rate was 90.7%; the control group basically recovered in 26 cases, markedly effective in 29 cases, the total effective rate was 73.3%. The difference between the two groups was significant (P <0.01), with statistical significance. ② The neurological impairment scores of the treatment group and the control group were improved before and after treatment, but the treatment group improved significantly compared with the control group (P <0.01), with statistical significance. Conclusion Low molecular weight heparin combined with aspirin in the treatment of cerebral infarction in improving hemiplegia, aphasia and other neurological symptoms and changes in blood coagulation has some effect, its strong effect, rapid onset, good effect, safe and reliable, in the clinical treatment of median Is to promote the application.