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英国一家富于创新的公司比切姆(Beecham)公司开发了两个复方抗生素新药,一个是奥格曼停(羟氨苄青霉素加棒酸钾),另一个是替曼停(羧噻吩青霉素加棒酸钾)。加入棒酸钾可有效地抑制人体中β-内酰胺酶对青霉素的阻力。这两种药已先后投放美国市场。本文着重介绍奥格曼停的情况。一、羟氨苄青霉素和棒酸钾的化学性质羟氨苄青霉素的化学名是α-氨基-4-羟苄青霉素三水物,分子式为C_(10)H_(19)N_3O_(?)S·3H_2O,分子量419.45,外观为白色或微黄白色结晶性粉末,溶于水,0.2%水溶液pH值为4.7。化学结构式为:
An innovative UK company, Beecham, has developed two new antibiotic compounds, one is Ogilvan (amoxicillin plus potassium clavulanate) and the other is teicmanidine Potassium acid). Adding potassium clavulanate effectively inhibits the resistance of human beta-lactamase to penicillin. These two drugs have been put on the American market. This article focuses on the case of Ogman stopped. First, the amoxicillin and potassium clavulanic acid chemical nature Amoxicillin is the chemical name of α-amino-4-ampicillin trihydrate, the molecular formula C_ (10) H_ (19) N_3O _ (?) S · 3H_2O, Molecular weight of 419.45, the appearance of white or yellowish-white crystalline powder, soluble in water, 0.2% aqueous solution pH value of 4.7. Chemical structure is: