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目的研究红厚壳(Calophyllum inophyllum Linn.)枝条的化学成分。方法采用硅胶柱色谱、凝胶柱色谱等方法进行分离纯化,根据理化常数和波谱数据鉴定结构。结果从红厚壳枝条中提取分离得到5个化合物,分别鉴定为:1,2,3-三羟基-5-甲氧基口山酮(1)、3,5-二羟基-1-甲氧基口山酮(2)、1,7-二羟基-3-甲氧基口山酮(3)、3-羟基-4-甲氧基口山酮(4)和12-甲氧基红厚壳素P(5)。结论以上5个化合物均为首次从该种植物中分离得到。采用MTT法对以上化合物进行了体外肿瘤细胞毒活性测试,实验结果表明,化合物1和5均显示了肿瘤细胞毒活性。
Aim To study the chemical constituents of the branches of Calophyllum inophyllum Linn. Methods The compounds were separated and purified by silica gel column chromatography and gel column chromatography. The structures were identified by physicochemical constants and spectral data. Results Five compounds were isolated and purified from Rhizome Chrysanthemum branches and identified as 1,2,3-dihydroxy-5-methoxy-2-methoxy-1-methoxy (2), 1,7-dihydroxy-3-methoxy colorant (3), 3-hydroxy-4-methoxypicolinone (4) Chitin P (5). Conclusion The above five compounds were isolated from this plant for the first time. The above compounds were tested for cytotoxicity using MTT assay. The results showed that both compounds 1 and 5 showed cytotoxicity.