60年前,有人发现活的瘤细胞能使碳水化合物转化成乳酸。此后许多年,人们假设肿瘤主要依赖糖酵解途径产生大量乳酸,而使细胞内的pH(pHi)偏酸性。以后,用微电极测定肿瘤pH似乎证实了这一假设。但现在知道这种测定主要反映了pHe,即间液(或细胞外液)的pH(范围在5.5～7.3之间)。磁 60 years ago, it was found that living tumor cells can convert carbohydrates into lactic acid. For many years thereafter, it was hypothesized that tumors rely mainly on the glycolytic pathway to produce large amounts of lactic acid, making the intracellular pH (pHi) acidic. Later, the use of microelectrodes to determine tumor pH seems to confirm this hypothesis. However, it is now known that this assay primarily reflects pHe, the pH of the interstitial fluid (or extracellular fluid) (ranging from 5.5 to 7.3). magnetic