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采用大鼠足跖肿胀法、小鼠耳肿胀法、热板法、扭体法进行跌打镇痛液的抗炎镇痛药理研究 ,并对 46 0例关节损伤患者随机分为治疗组 35 0例与对照组 (正骨水 ) 110例进行临床疗效观察。结果表明本品能抑制大鼠足跖肿胀、抑制小鼠耳肿胀、提高小鼠痛阈值、抑制由冰醋酸引起的扭体反应 ,有显著的抗炎镇痛作用。临床观察治疗组总有效率 96 86 % ,副反应发生率 0 43% ;对照组总有效率 77 2 7% ,副反应发生率 3 6 4%。二组疗效比较有显著性差异 (P <0 0 1)。本品治疗关节及肌肉损伤有显著疗效 ,且副反应小。
The pharmacological study of anti-inflammation and analgesia of ornithism and analgesia was carried out by rat paw edema, mouse ear swelling, hot plate and writhing, and 460 patients with joint injury were randomly divided into treatment group 35 0 The clinical and curative effect observations were made between 110 patients in the control group and Zhengshishui group. The results showed that this product can inhibit the swelling of rat paws, inhibit ear swelling of mice, increase the pain threshold of mice, inhibit the writhing response caused by glacial acetic acid, and have significant anti-inflammatory and analgesic effects. The total effective rate of the clinical observation and treatment group was 96 86%, and the incidence of side effects was 0 43%. The total effective rate in the control group was 77 27%, and the side effect rate was 36.4%. There was a significant difference in efficacy between the two groups (P < 0 01). This product has a significant effect on the treatment of joint and muscle damage, and the side effects are small.