Introduction Metformin(1,1-dimethylbiguanide)(Fig.1)is anoralanti-hyperglycemicagentusedinthetreat- mentofnon-insulin-dependentdiabetesmellitus (type ).Owingtoitsweight-decreasingand serumlipid-normalizingeffects,itisespeciallyrec- ommendedforobesepatient Introduction Metformin (1,1-dimethylbiguanide) (Fig.1) is anoralanti-hyperglycemic agent used in treatment-non-insulin-dependent diabetes mellitus (type) .Owingtoitsweight-decreasingand serumlipid-normalizingeffects, itispeciallyrec- ommendedforobesepatient