目的：探讨非小细胞肺癌Non－Small Cell Lung Cancer NSCLC多种耐药相关基因MRP、MDR1、c－erbB－2表达与细胞凋亡及相关基因bc1－2、c－myc的关系与意义。方法：RT－PCR、免疫组化分析多种耐药、凋亡相关基因mRNA及蛋白表达，原位末端标记Terminal deoxynucleotidyl transferaseTdT－mediated biotin dUTP nick end－labelingTUNEL检测凋亡细胞。结果：63例NSCLC MRP、MDR1、c－erbB－2、bc1－2、c－myc mRNA阳性率分别为81．0％51／63、38．1％24／63、47．6％30／63、65．1％41／63、76．2％48／63，均高于相应的蛋白表达水平分别为74．6％、34．9％、46．0％、61．9％、71．4％，二者具高度相关性相关系数r＝＋0．76以上P＜0．02，5例癌旁组织仅2例c－myc弱阳性，余皆阴性。c－myc、bc1－2与c－erbB－2呈正相关r＝＋0．54P＝0．001r＝＋0．48P＝0．023，与MRP、MDR1无相关性。凋亡指数与bc1－2负相关r＝－0．58P＝0．017，与MRP、MDR1、c－erbB－2、c－myc无相关性；腺癌及鳞癌化疗有效组凋亡指数均数27．2±2．130．5±1．8高于化疗无效组9．4±1．312．6±2．4P＝0．001P＝0．004，bcl－2、MRP、c－erbB－2阳? Objective: To investigate the relationship between MRP, MDR1, c-erbB-2 expression and apoptosis and related genes bcl-2, c-myc in non-small cell lung cancer (Non-Small Cell Lung Cancer). significance. METHODS: RT-PCR and immunohistochemistry were used to analyze the mRNA and protein expressions of various drug-resistance and apoptosis-related genes. In situ end-labeling was performed. Terminal deoxynucleotidyl transferase (TdT)-mediated biotin dUTP nick end-labeling (TUNEL) was used to detect apoptotic cells. . Results: The positive rates of MRP, MDR1, c-erbB-2, bc1-2, c-myc mRNA in 63 NSCLC were 81.0%, 51/63, 38.1%, 24/63, and 47.6, respectively. %30/63, 65.1%41/63, 76.2%48/63, all higher than the corresponding protein expression levels74.6%, 34.9%, 46. 0%, 61.9%, 71.4%            They are highly correlated  Correlation coefficient r = +0.76 or more  P < 0.02 , 5 cases of paracancerous tissue only 2 cases of weak c-myc positive , I was negative. There was a positive correlation between c-myc and bcl-2 and c-erbB-2 (r=+0.54P=0.001r=+0.48P=0.023), which was not associated with MRP and MDR1. Apoptosis index was negatively correlated with bcl-2 (r=-0.58P=0.017), and had no correlation with MRP, MDR1, c-erbB-2, c-myc; adenocarcinoma and squamous cell carcinoma chemotherapy were effective Apoptotic index mean 27.2±2.130.5±1.8 was higher than that of chemotherapy-negative group9.4±1.312.6±2.4P=0.001 P=0.004, bcl-2, MRP, c-erbB-2 positive?