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本文报告两类二氮陆圜衍生物:(α,ω-双(1-取代基-4-二氮陆圜基)烷类盐酸盐,及l,2-双(1’-取代基-4’-二氮陆圜基乙氧基)乙烷盐酸盐)的制备。α,ω-双(1-乙氧碳酰基-4-二氮陆圜基)烷类、及α,ω-双(1-二乙氨基碳酰基-4-二氮陆圜基)烷类,可由1-取代基二氮陆圜与相当的α,ω-二溴烷,经碳酸氢钠作用制成。 1.2-双(1’-乙氧碳酰基-4’-二氮陆圜基乙氧基)乙烷、及1,2-双(1’-二乙氨基碳酰基-4’-二氮陆圜基乙氧基)乙烷,可由1,2-双(β-氯乙氧基)乙烷先和碘化钠作用,制成碘化物,然后再与相当的1-取代基二氮陆圜经碳酸氢钠作用制成。上述两类化合物的1-甲基二氮陆圜衍生物,均系由过量的1-甲基二氮陆圜,与相当的α,ω-二溴烷或1,2-双(β-氯乙氧基)乙烷在乾燥苯中作用制成。
Two types of diazepam derivatives, α, ω-bis (1-substituted-4-diazepinium) alkanes hydrochloride and 1,2-bis 4’-diazinonylethoxy) ethane hydrochloride). α, ω-bis (1-ethoxycarbonyl-4-diazepinyl) alkanes and α, ω- bis (1-diethylaminocarbonyl- By 1-substituted nitrogenous landfill with the equivalent of α, ω-dibromo, made by the role of sodium bicarbonate. 1.2-bis (1’-ethoxycarbonyl-4’-diazepinylethoxy) ethane and 1,2-bis (1’-diethylaminocarbonyl-4’-diazonium Ethoxy) ethane, can be 1,2-bis (β-chloroethoxy) ethane and sodium iodide role first, the formation of iodide, and then with the equivalent of 1 - Made of sodium bicarbonate. The 1-methyldiazepine derivatives of the above two classes of compounds are all derived from an excess of 1-methyldiazepine with an equivalent α, ω-dibromoalkane or 1,2-bis (β-chloro Ethoxy) ethane made in dry benzene.