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目的:探讨人体被动暴露于吸咽后的生物标记(血清可替宁浓度)与冠心病和卒中风险的关系。设计:全科医学(英国地区心脏研究)中的前瞻性人群研究。参加者:英国18个城市的4729名男士,提供了1978至1980年的详细吸烟状况及基础血样(用于可替宁分析)。主要结果测定指标:在20年随访期内发生的主要冠心病和卒中事件(致死和非致死性)。结果:将2105名声称不吸烟且血清可替宁浓度<14．1ng／ml的男士,按基线可替宁浓度分成同等规模的四组。四组中第二组(可替宁浓度0．8-1．4ng／ml)、第三组(1．5-2．7ng／ml)、第四组(2．8-14．0ng／ml)分别与第一组(≤0．7ng／ml)比
OBJECTIVE: To investigate the relationship between biomarker (serum cotinine concentration) and the risk of coronary heart disease and stroke after passive exposure to human pharynx. Design: Prospective population study in general practice (Heart study in the UK). PARTICIPANTS: 4729 men from 18 cities in Britain provided detailed smoking status and baseline blood samples (for cotinine analysis) from 1978 to 1980. MAIN OUTCOME MEASURES: Major coronary heart disease and stroke events (lethal and non-fatal) that occurred during a 20-year follow-up period. RESULTS: A total of 2,105 men who reported not to smoke and had serum cotinine concentrations <14.1 ng / ml were divided into four equal-sized groups at baseline cotinine concentrations. The second group (cotinine concentration 0.8-1.4 ng / ml), the third group (1.5-2.7 ng / ml), the fourth group (2.8-14.0 ng / ml) ) Were compared to the first group (≤0.7 ng / ml) respectively