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目的 :比较血管紧张素受体拮抗剂 (AT1RA)和血管紧张素转换酶抑制剂 (ACEI)的肾脏保护作用 ,观察这两类药物对肾脏局部肾素 -血管紧张素系统的影响。方法 :肾病综合征模型由反复给SD大鼠腹腔注射嘌呤霉素诱导而成。2 8只大鼠随机分为 4组 :正常对照组、肾病对照组、AT1RA治疗组和ACEI治疗组。 12周后收集血、尿和肾组织标本进行检测。结果 :两治疗组尿蛋白明显少于肾病对照组 ,且到实验期末 ,肾功能仍在正常范围 ,肾小球和肾间质损伤指数也低于肾病对照组 ,但两治疗组间无明显差异 (P >0 0 5 )。肾病对照组的肾组织ACE活性、血管紧张素Ⅱ浓度显著高于正常对照组(P <0 0 1)。在ACEI和AT1RA治疗组 ,肾组织ACE活性和ANGⅡ浓度显著低于肾病对照组 (P <0 0 1)。结论 :AT1RA和A CEI在肾病综合征进行性肾损伤中 ,具有相似的肾脏保护作用 ,这种作用可能与抑制肾脏局部的ANGⅡ有关
OBJECTIVE: To compare the renal protective effects of angiotensin II receptor antagonist (AT1RA) and angiotensin-converting enzyme inhibitor (ACEI), and to observe the effects of these two drugs on renal renin-angiotensin system. Methods: Nephrotic syndrome model induced by repeated intraperitoneal injection of puromycin into SD rats. 28 rats were randomly divided into 4 groups: normal control group, nephropathy control group, AT1RA treatment group and ACEI treatment group. Blood, urine and kidney tissue samples were collected after 12 weeks for testing. Results: Urinary protein in two treatment groups was significantly lower than that in nephropathy control group. At the end of the experiment, renal function was still in the normal range, glomerular and renal interstitial injury index was lower than that of nephropathy control group, but there was no significant difference between the two treatment groups (P> 0 0 5). Nephropathy control group renal ACE activity, angiotensin Ⅱ concentration was significantly higher than the normal control group (P lt; 0 1). In ACEI and AT1RA treatment group, ACE activity and ANG Ⅱ concentration in renal tissue were significantly lower than those in control group (P <0.01). CONCLUSION: AT1RA and A CEI have similar protective effects on renal injury induced by nephrotic syndrome, which may be related to the inhibition of local ANGⅡ