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目的评价清热活血法联合西乐葆治疗痛风性关节炎临床疗效及其安全性。方法选取台州市中心医院就诊的104例痛风性关节炎患者作为研究对象,采用随机数字表法将其分为观察组和对照组,每组52例。对照组患者给予西乐葆治疗;观察组患者在对照组的基础上给予清热活血法治疗,2组治疗时间均为7 d。治疗后观察2组患者临床疗效;治疗后第1、3、5、7天分别采用VAS评分对2组患者痛风关节疼痛程度进行评价;治疗后,比较2组患者关节红肿消失时间及关节疼痛缓解时间;治疗前后分别检测患者白细胞、肿瘤坏死因子-α及C-反应蛋白水平;观察治疗期间不良反应发生情况。结果观察组患者治愈率、显效率及总有效率分别为26.9%、46.2%和96.2%,均明显高于对照组(P<0.05);治疗第5天及第7天,观察组患者VAS评分分别为(1.31±0.31)分和(0.41±0.13)分,均明显低于对照组(P<0.05);观察组患者关节疼痛缓解时间和关节红肿消失时间均明显短于对照组(P<0.05);治疗后观察组白细胞、肿瘤坏死因子-α及C-反应蛋白水平分别为(6.82±1.53)×109/L、(63.2±4.4)pg/ml和(12.9±1.6)mg/L,均明显低于对照组(P<0.05);治疗期间2组均未发生严重不良反应。结论清热活血法联合西乐葆治疗痛风性关节炎的临床疗效及安全性均较好,值得开展深入研究。
Objective To evaluate the clinical efficacy and safety of Qingrehuoxue combined with Celebrex in the treatment of gouty arthritis. Methods Totally 104 cases of gouty arthritis treated in Central Hospital of Taizhou City were selected as research object. The patients were divided into observation group and control group by random number table method, with 52 cases in each group. Patients in the control group were treated with Celebrex; patients in the observation group were treated with the method of clearing heat and activating blood circulation on the basis of the control group, and the treatment time was 7 days in both groups. After treatment, the clinical curative effect of the two groups was observed. VAS score was used to evaluate the degree of pain in the two groups on the 1st, 3rd, 5th, 7th day after treatment. After the treatment, the disappearance of joint swelling and joint pain relief Time; before and after treatment were detected in patients with leukocytes, tumor necrosis factor-α and C-reactive protein levels; observed during treatment of adverse reactions. Results The cure rate, effective rate and total effective rate in observation group were 26.9%, 46.2% and 96.2% respectively, which were significantly higher than those in control group (P <0.05). On the 5th and 7th day after treatment, the VAS score (1.31 ± 0.31) and (0.41 ± 0.13) points respectively, which were significantly lower than those in the control group (P <0.05). The pain relief time and joint disappearance time in the observation group were significantly shorter than those in the control group (P <0.05) ); The levels of leukocyte, tumor necrosis factor-α and C-reactive protein in the observation group were (6.82 ± 1.53) × 109 / L, (63.2 ± 4.4) pg / ml and (12.9 ± 1.6) mg / L Significantly lower than the control group (P <0.05); no serious adverse reactions occurred in the two groups during the treatment. Conclusion The clinical efficacy and safety of Qingrehuoxue combined with Celebrex in the treatment of gouty arthritis are good, which deserves further study.