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目的了解潍坊市2013-2014年引起手足口病(实验室确诊)的病原体柯萨奇病毒A16型(CA16)的流行状况,从而制定更良好的预防措施,降低发病率。方法采用实时荧光定量法对2013-2014年潍坊市所辖的16个县市上送的共1318例手足口病患者粪便标本进行核酸检测,并从地域、年龄、性别、职业、病例性质等角度对结果进行分析。结果 2013年实验室确诊203例CA16阳性标本,2014年为152例,发病地域以中西部居多,男童多于女童,两年男女发病比例分别为1.67:1及1.76:1,3岁以下散居幼童居多,病例性质上普通病例占绝大多数,重症最少,分别为2例及3例。结论加大宣传力度,强化控制措施,尤其对3岁以下散居幼儿家庭,有利于更好地控制由CA16引起的感染,降低发病率。
Objective To understand the prevalence of Coxsackievirus A16 (CA16), a pathogen causing hand-foot-mouth disease (laboratory diagnosis) in Weifang from 2013 to 2014 so as to make better preventive measures and reduce morbidity. Methods The real-time fluorescence quantitative method was used to detect the nucleic acid of 1318 hand, foot and mouth disease patients from 16 counties under the jurisdiction of Weifang City from 2013 to 2014. The results showed that there was no significant difference Analyze the results. Results A total of 203 CA16 positive specimens were confirmed in laboratory in 2013, 152 cases in 2014. Most of the cases were found in the Midwest and more boys than girls. The prevalence rates of male and female in two years were 1.67: 1 and 1.76 respectively: The majority of young children, the vast majority of common cases in the nature of cases, the least severe cases were 2 cases and 3 cases. Conclusion Increasing publicity and strengthening control measures, especially for diaspora families under 3 years of age, are conducive to better controlling the infection caused by CA16 and reducing the incidence.