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预先使用西米替丁在统计学上与雷尼替丁或安慰剂比较,可延长丙咪嗪的血浆半衰期并显著增加 AUC。西米替丁后使用的丙咪嗪表观口服清除率降低。建议当使用西米替丁时,丙咪嗪的剂量需要减少50%。一项研究比较雷尼替丁和西米替丁对口服丙咪嗪处置的效果已完成。
Premedical use of cimetidine compared statistically with ranitidine or placebo extended the plasma half-life of imipramine and significantly increased AUC. The apparent oral clearance of imipramine used after cimetidine was reduced. It is recommended that when using cimetidine, the dose of imipramine needs to be reduced by 50%. A study comparing the effects of ranitidine and cimetidine on oral imipramine treatment has been completed.