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目的应用替莫唑胺(TMZ)以司莫司丁(CCNU)作为对照研究两者对恶性脑胶质瘤化疗的有效性。方法一年内入组合格患者55例,随机分成两组,按体表面积分别给以两种药物化疗并每月进行临床随访、定期复查头颅强化CT或MRI与化疗前资料比较判断病情变化。结果影像所示肿瘤实体的缓解率TMZ组为44．74％,CCNU组为11．77％,P=0．017。临床功能改善率TMZ 组为53％,CCNU组为12％,P=0．017。结论 TMZ比CCNU有较高的缓解率,更好的改善临床功能,可有效的提高生活质量。希望更长期更广泛的研究验证和改进本试验。
Objective To study the efficacy of temozolomide (TMZ) in the chemotherapy of malignant glioma by taking CCNU as a control. Methods Fifty-five eligible patients in one year were divided into two groups at random. The patients were given two kinds of chemotherapy and monthly clinical follow-up according to the body surface area. The changes of the patient’s condition were analyzed by periodic review of craniofacial CT or MRI before chemotherapy. Results The imaging results showed that the remission rate of tumor entities was 44.74% in TMZ group and 11.77% in CCNU group, P = 0.017. Clinical improvement rates were 53% in the TMZ group and 12% in the CCNU group, P = 0.017. Conclusion TMZ has a higher remission rate than CCNU, better improve clinical function, which can effectively improve the quality of life. It is hoped that more long-term and broader research will validate and improve this test.