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目的 :考察氟康唑胶囊和片剂的溶出度。方法 :采用浆法测定溶出度 ,以盐酸溶液 ( 9- 10 0 0 )作为溶出介质 ,转速 80r·min-1,温度 ( 37.0± 0 .5 )℃ ;用紫外分光光度法测定含量。结果 :四个不同厂家的氟康唑胶囊和片剂溶出度均符合中国药典 2 0 0 0年版规定 ,但不同厂家制剂溶出度稳定性存在差异。结论 :此方法可用于氟康唑口服剂型的溶出度监测
Objective: To investigate the dissolution of fluconazole capsules and tablets. Methods: The dissolution rate was determined by slurry method. The content of hydrochloric acid solution (9-10 0 0) was used as the dissolution medium at the speed of 80 r · min-1 and temperature (37.0 ± 0. 5) ℃. The content was determined by UV spectrophotometry. Results: The dissolution rates of fluconazole capsules and tablets from four different manufacturers were in accordance with the requirements of the Chinese Pharmacopoeia 2000 edition, but there were differences in the dissolution stability of different manufacturers. Conclusion: This method can be used for the dissolution monitoring of oral dosage forms of fluconazole