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在过去10年间,采用同胞兄弟姊妹的骨髓移植治疗再生障碍性贫血(再障),虽然取得令人鼓舞的效果,但在年龄较大的患者中,以免疫抑制剂糖皮质激素或抗胸腺细胞球蛋白(antithymus globulin,ATG)治疗的热情仍然是时高时低的。美国最新的数字显示,以 ATG 治疗成人再障的疗效为41%。由于大剂量应用皮质激素所出现的毒性反应,以及 ATG制剂的不稳定性,人们用雄烷(androstane)衍生物治疗再障的兴趣便有所增加。本文报道采用雄烷治疗成人再障的结果。
In the past 10 years, the treatment of aplastic anemia (aplastic anemia) with siblings of sibling siblings, although encouraging, has been reported in older patients with immunosuppressive glucocorticoids or anti-thymocytes Antithymus globulin (ATG) treatment is still high and low enthusiasm. The latest US figures show that the ATG treatment of adult patients with aplastic anemia was 41%. There is an increased interest in the treatment of aplasia with androstane derivatives due to the toxic effects of high doses of corticosteroids and the instability of ATG preparations. This article reports the results of the treatment of adult aplasia with androstane.