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脱屑性间质性肺炎(Desquamative In—stertitial Pneumonitis,DIP)由Liebow 等在1965年首次提出,并描述为一种原因不明的儿童慢性疾病,临床特征是肺泡上皮细胞增生,脱落,并坠入肺泡腔中。DIP 有别于其它类型的间质性肺炎(尤其是病理组织改变、X 线特征和治疗效果及预后等),国外已将DIP 单列为一个独立疾病。发病原因DIP 的病因目前尚不清楚。曾有多位作者如Schatz、Hilman、Daniele 等报道本病有类风湿因子、抗核抗体和红斑狼疮现象的存在,Tubbe 用电镜观察肺组织活检,在超微结构中,未能发现病毒颗粒;Patche—
Desquamative In-stertitial Pneumonitis (DIP) was first proposed by Liebow et al in 1965 and described as an chronic childhood disease of unknown cause characterized clinically by alveolar epithelial cell hyperplasia, loss and cessation Alveolar cavity. DIP is different from other types of interstitial pneumonia (especially pathological changes, X-ray characteristics and treatment effects and prognosis, etc.), DIP has been singled out as an independent disease abroad. The etiology of DIP is not yet clear. A number of authors such as Schatz, Hilman and Daniele reported the presence of rheumatoid factor, antinuclear antibodies and lupus erythematosus. Tubbe electron microscopy was used to observe the lung biopsy. In the ultrastructure, virus particles could not be found. Patche-