目的　分析皮下脂膜炎样T细胞淋巴瘤的病理组织学形态、诊断及鉴别诊断。方法　报道 2例发生在腿部的病例 ,从临床病理、免疫表型和基因特征等方面进行观察。结果　 2例肿瘤均呈脂膜炎样生长 ,肿瘤细胞围绕单个脂肪呈花瓣状排列 ,核碎裂体易见 ,有侵蚀性坏死性血管炎改变 ,伴明显的出血和坏死 ,并可出现大片状凝固性坏死。肿瘤表达T细胞免疫表型 ,有TCRβ基因重排。 1例从发病到死亡仅 3月余 ,另 1例半年内进展为多处皮肤病变。结论　此病是一种以累及皮下脂肪组织为主的特殊类型的淋巴瘤 ,应与良性脂膜炎及其它皮肤良性坏死性疾病相鉴别 Objective To analyze the histopathological morphology, diagnosis and differential diagnosis of subcutaneous panniculitis-like T-cell lymphoma. Methods Two cases in the leg were reported. The clinical pathology, immunophenotype and gene characteristics were observed. Results The tumors of both cases showed panniculitis-like growth. The tumor cells were arranged in a petaloid shape around the individual fat. The nuclear fragmentation was easy to see. There was an inflammatory necrotizing vasculitis with obvious hemorrhage and necrosis, and a large area appeared. Coagulative necrosis. The tumor expresses a T cell immunophenotype with TCRβ gene rearrangement. One case lasted more than 3 months from the onset to death, and the other case progressed to multiple skin lesions within half a year. Conclusion The disease is a special type of lymphoma that involves subcutaneous adipose tissue and should be distinguished from benign panniculitis and other benign necrotizing skin diseases.