目的研究血清甲胎蛋白(AFP)、丙氨酸氨基转移酶(ALT)、总胆红素(STB)测定对慢性乙型肝炎两种模式的临床监测意义,比较两种模式的差异。方法对符合大、小三阳模式病人进行相应项目检测,用同期体检人群进行对比,并进行统计学分析。结果大、小三阳组差异无统计学意义,大三阳组与对照组ALT、STB差异有统计学意义(P<0.01),小三阳组与对照组AFP、ALT、STB差异均有统计学意义(AFP:P<0.05;ALT、STB:P<0.01)。结论动态观察血清AFP、ALT、STB变化有利于对慢性乙型肝炎大小三阳模式感染者病情的监测。 Objective To study the clinical significance of serum alpha-fetoprotein (AFP), alanine aminotransferase (ALT) and total bilirubin (STB) in two modes of chronic hepatitis B, and to compare the differences between the two modes. Methods The patients who met the large and small Sanyang model were tested for the corresponding items, compared with the physical examination population of the same period and analyzed statistically. Results There was no significant difference between the large and small Sanyang group, the difference of ALT and STB between the Sansanyang group and the control group was statistically significant (P <0.01), the difference between the Sanshan group and the control group was statistically significant (AFP: P <0.05; ALT, STB: P <0.01). Conclusion Dynamic observation of the changes of serum AFP, ALT and STB is beneficial to the monitoring of the severity of hepatitis B virus infection in Sanyang model.