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小管间质性肾炎 -葡萄膜炎综合征是一种新发现的疾病 ,多发生于青少年女性。其全身表现主要有乏力、体重减轻、发热、恶心呕吐、腹痛或腰痛 ,眼部一般表现为双眼非肉芽肿性前葡萄膜炎 ,葡萄膜炎和间质性肾炎发生的时间间隔一般在 1年内。实验室检查发现贫血、红细胞沉降率增高、肾功能不全、尿β2 -微球蛋白升高 ,肾活检显示肾间质炎症细胞浸润。细胞免疫可能在其发病中起重要作用。治疗以局部和全身应用糖皮质激素为主 ,预后较好 ,肾炎一般不复发 ,而葡萄膜炎易复发。
Tubulointerstitial nephritis-uveitis syndrome is a newly discovered disease that occurs mostly in adolescent girls. Its main manifestations of fatigue, weight loss, fever, nausea and vomiting, abdominal pain or back pain, the general performance of the eyes of non-granulomatous anterior uveitis, uveitis and interstitial nephritis generally occur within 1 year interval . Laboratory tests revealed anemia, increased erythrocyte sedimentation rate, renal insufficiency, elevated urinary β2-microglobulin, and renal biopsy showing interstitial inflammatory cell infiltration. Cellular immunity may play an important role in its pathogenesis. Treatment of topical and systemic glucocorticoid-based, good prognosis, nephritis generally does not recur, and uveitis relapse.