论文部分内容阅读
目的:通过回顾性分析各种围产期危险因素对新生儿缺氧缺血性脑病(HIE)发生的可能影响,寻求预防HIE发生及改善其预后的方法。方法:对302例HIE患儿性别、胎龄、出生体重、临床表现、母亲孕期病史及分娩情况进行回顾性调查分析。同时随机抽取128例同期住院的新生儿肺炎、新生儿黄疸患儿作对照,应用logistic多元逐步回归分析的方法筛选HIE发病的危险因素。结果:两组患儿中10个围产因素存在统计学差异。应用logistic多元逐步回归分析结果显示:分娩方式、羊水污染、胎膜早破、脐带异常、Apgar评分异常等为主要危险因素。结论:增强孕妇医学保健意识、加强围产期保健、提高基层医疗机构产科质量、根据不同产妇和胎儿的具体情况,采取适当的个体化干预措施,对预防和减少新生儿HIE发生,降低围产儿死亡率和致残率具有重要意义。
OBJECTIVE: To seek ways to prevent the occurrence of HIE and improve its prognosis by retrospectively analyzing the possible effects of various perinatal risk factors on neonatal hypoxic-ischemic encephalopathy (HIE). Methods: The gender, gestational age, birth weight, clinical manifestations, mother’s pregnancy history and childbirth in 302 HIE children were analyzed retrospectively. At the same time, 128 children with neonatal pneumonia and neonatal jaundice hospitalized in the same period were randomly selected as controls. The risk factors of HIE were screened by logistic multiple stepwise regression analysis. Results: There were statistical differences in 10 perinatal factors between the two groups. Logistic multiple stepwise regression analysis showed that mode of delivery, amniotic fluid contamination, premature rupture of membranes, abnormal umbilical cord injury and Apgar score were the main risk factors. Conclusion: To enhance pregnant women’s awareness of medical care, strengthen perinatal care and improve obstetric quality of primary medical institutions, according to the specific circumstances of different mothers and fetuses, take appropriate individual interventions to prevent and reduce neonatal HIE, reduce perinatal Mortality and morbidity rates are important.