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目的:以黄连解毒汤模拟体系为研究对象,探讨中药水提液超滤过程污染机制,为中药膜分离技术应用系统的优化设计奠定基础。方法:采用系统模拟的方法,以超滤膜过程中通量变化、膜污染度、成分截留率、小分子物质吸附速率和吸附量等为指标,研究黄连解毒汤复方中小分子药效物质和共性高分子物质的超滤行为及相互影响。结果:黄连解毒汤模拟体系中,小檗碱和栀子苷PS5K超滤膜透过率在90%以上,淀粉、果胶、蛋白质3种高分子物质的截留率为100%;但模拟溶液中由于高分子物质的存在造成小檗碱和栀子苷的膜透过率大大降低,膜污染和膜通量衰减加剧;小檗碱和栀子苷的膜吸附行为也因为高分子物质的存在而发生了改变。结论:黄连解毒汤复方溶液中,高分子物质的存在是造成超滤膜污染和药效物质损失的主要因素,其中主要污染物是淀粉和果胶。
OBJECTIVE: To investigate the mechanism of the ultrafiltration of traditional Chinese medicine aqueous extract by using the simulation system of Huanglian Jiedu Decoction as the research object, and to lay the foundation for the optimal design of the traditional Chinese medicine membrane separation technology application system. Methods: By means of systematic simulation, the changes of flux, membrane fouling, component rejection, adsorption rate of small molecules and adsorption capacity of ultrafiltration membrane were used as indices to study the effect of small and medium molecular weight pharmacological substances Ultrafiltration behavior and interaction of macromolecules. Results: The permeation rate of berberine and geniposide PS5K ultrafiltration membrane was over 90% in the simulation system of Huanglian Jiedu Decoction, and the rejection of three macromolecules such as starch, pectin and protein was 100%. However, in simulated solution Due to the presence of macromolecular substances, the membrane permeability of berberine and geniposide is greatly reduced, and the membrane fouling and membrane flux decay exacerbated. The membrane adsorption behavior of berberine and geniposide is also due to the presence of macromolecular substances Has changed. CONCLUSION: The existence of macromolecules in the compound solution of Huanglian Jiedu Decoction is the main factor causing the pollution of ultrafiltration membrane and the loss of medicinal substances. The main pollutants are starch and pectin.