丁胺卡那霉素临床用于对其他氨基甙类抗生素耐药菌株的感染,是一种抗菌作用较强的氨基甙类抗生素,其抗菌谱广,疗效确切,使用方便,不需作皮试,临床应用广泛。但临床医师对其肾毒性不够重视,特别在基层医疗单位有滥用及超剂量应用现象,因而常导致严重不良后果。笔者疮自1994—1996年共观察丁胺卡那霉素所致小儿肾损害22例。现报告如下。 1 临床资料 丁胺卡那霉素按小儿常用剂量为10mg— Amikacin clinically used for other aminoglycoside antibiotic-resistant strains of infection is a strong antibacterial aminoglycoside antibiotics, its broad antibacterial spectrum, the exact effect, easy to use, do not need to make a skin test , A wide range of clinical applications. However, clinicians are not paying enough attention to their nephrotoxicity, especially abuse and overdosing in primary medical units, which often leads to serious adverse consequences. The author sores from 1994 to 1996 observed a total of 22 cases of renal damage caused by amikacin in children. The report is as follows. 1 clinical data amikacin by pediatric common dose of 10mg-