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目的探讨依那西普治疗强直性脊柱炎(AS)的临床疗效。方法选取德阳市人民医院2010年12月—2012年10月收治的AS患者156例,随机分成观察组和对照组,各78例。观察组给予依那西普治疗,对照组给予柳氮磺胺吡啶、甲氨蝶呤治疗。比较治疗前后两组患者的AS疾病活动指数(BASDAI),AS功能指数(BASFI),采用视觉模拟评分法(VAS)评价脊柱痛和夜间痛,晨僵时间、指地距以及血清MMP-3、红细胞沉降率(ESR)及C-反应蛋白(CRP)水平。结果两组患者治疗前的BASDAI、脊柱痛VAS评分、晨僵时间、夜间痛VAS评分、BASFI、指地距比较,差异无统计学意义(P>0.05);治疗后,观察组患者的BASDAI、脊柱痛VAS评分、夜间痛VAS评分、BASFI低于对照组,晨僵时间短于对照组,指地距短于对照组,差异有统计学意义(P<0.05)。两组患者治疗前MMP-3、ESP和CRP水平比较,差异无统计学意义(P>0.05);治疗后观察组患者的MMP-3、ESP和CRP水平均低于对照组,差异有统计学意义(P<0.05)。结论依那西普治疗AS的临床疗效显著,患者相关临床指标改善明显。
Objective To investigate the clinical efficacy of etanercept in the treatment of ankylosing spondylitis (AS). Methods 156 cases of AS patients who were treated in Deyang People’s Hospital from December 2010 to October 2012 were randomly divided into observation group and control group with 78 cases each. The observation group was given etanercept, while the control group was given sulfasalazine and methotrexate. The AS disease activity index (BASDAI) and AS function index (BASFI) were compared between the two groups before and after treatment. The visual analogue scale (VAS) was used to evaluate spinal pain and nocturnal pain, morning stiffness time, Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. Results BASDAI, VAS scores of spinal pain, morning stiffness, night pain VAS score, BASFI, mean distance between the two groups had no significant difference (P> 0.05). After treatment, the BASDAI, VAS scores of spinal pain, VAS scores of night pain, BASFI lower than the control group, morning stiffness was shorter than the control group, referring to the distance is shorter than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the levels of MMP-3, ESP and CRP between the two groups before treatment (P> 0.05). The levels of MMP-3, ESP and CRP in the observation group were lower than those in the control group after treatment Significance (P <0.05). Conclusion The clinical efficacy of etanercept in the treatment of AS is significant, and the relevant clinical indexes of patients are improved obviously.