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天然牛黄是来自个别牛体的胆结石,早在《神农本草经》中就列为上品,是一种常用的名贵中药因产量甚少,至今仍为紧缺药物。为了解决牛黄药源的稀缺,科研人员根据牛体患胆结石的发病机制,人为的造成牛体胆囊病态,使之形成牛黄。江西省赣州、吉安、松湖、望成等地据此原理进行了人工培育牛黄的试验研究,并取得一定的成效。为了对质量进行评价,我们对江西省人工培育的牛黄进行了化学分析。据报道牛黄所合成份有胆红素、胆酸、胆固醇、脂肪酸及钙,铁、钾、钠等无机离子,药理研究表明,上述化学物质中,胆红素与胆酸是牛黄的主要有效成份。因此,对牛黄中所含的胆红素及胆酸进行定性、定量的分析,可以作为评价牛黄质量的指标之一。我们曾以天然金山牛黄为对照品,对江西省赣州、吉安、松湖、望成人工培育牛黄进行了化
Natural bezoar is a gallstone derived from individual cattle. As early as in the “Shen Nong Ben Cao Jing”, it was listed as a top grade product. It is a commonly used valuable traditional Chinese medicine which is still a scarce drug because of its low yield. In order to solve the scarcity of bezoar sources, researchers based on the pathogenesis of gallstones in cattle, human gallbladder disease caused by the state, so that the formation of bezoar. Ganzhou, Ji’an, Songhu, and Wangcheng in Jiangxi Province have conducted experimental research on the artificial cultivation of bezoar based on this principle and achieved certain results. In order to evaluate the quality, we conducted a chemical analysis of the artificially cultivated bezoar in Jiangxi Province. It has been reported that the synthesis of bezoar contains bilirubin, bile acids, cholesterol, fatty acids and calcium, inorganic ions such as iron, potassium and sodium. Pharmacological studies have shown that among the above chemical substances, bilirubin and bile acid are main active ingredients of bezoar. . Therefore, the qualitative and quantitative analysis of bilirubin and bile acid contained in bezoar can be used as one of the indexes to evaluate the quality of bezoar. We used the natural Jinshan bezoar as a reference to carry out the cultivation of artificially cultivated bezoar in Ganzhou, Ji’an, Songhu, and Wangcheng of Jiangxi Province.