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目的 探讨厚皮厚骨膜综合征的治疗 ,并初步观察其病理变化。方法 1990～ 2 0 0 2年我们为 5例厚皮厚骨膜综合征患者面部采用手术治疗 ,并对病变组织行组织学检查。结果 手术治疗可明显改善患者面部皮肤皱褶的表现 ,组织学检查表明病变部位皮肤真皮胶原纤维层增生、增厚 ,细胞及间质PAS阳性物质增多。结论 厚皮厚骨膜综合征的发病可能与成纤维细胞生物活性改变有关。目前尚缺乏有效的治疗手段 ,手术可一定程度改善患者面部皮肤皱褶“老化”的现象。
Objective To investigate the treatment of thick-skinned periosteum syndrome and to observe its pathological changes. Methods From 1990 to 2002, we treated the facial of 5 patients with thick-skinned periosteum syndrome and performed histological examination on the diseased tissues. Results Surgical treatment can significantly improve the performance of facial skin folds. Histological examination showed that hyperplasia, thickening of dermal collagen fibrils in the lesion site and an increase of PAS positive cells in the cells and interstitium. Conclusion The incidence of thick periost periosteal syndrome may be related to the changes of fibroblast biological activity. Currently there is a lack of effective treatment, surgery to a certain extent, patients with facial wrinkles improve the “aging” phenomenon.