以某化纤厂纺丝车间工龄在10年以上、年龄在45岁以下的76名CS2作业工人作为接触组，同一工厂棉浆车间内选择相同年龄和工龄范围、曾经接触过CS2但现在已停止CS2接触5年以上的33名工人作为干预组，从未接触过CS2的23名工人作为对照组，进行流行病学横断面调查以了解CS2对工人血清铜、锌的影响。结果显示：接触组SCu和SZn含量均低于对照组（P＝0．0001）；用多元逐步回归分析控制了一些混杂因素后进一步显示，SCu和SZn含量均与CS2接触有一定的关系（偏相关系数分别为-02374和-02536），且CS2对SCu和CSn含量均起负贡献（偏回归系数β分别为-10．4173和-8．4175）。提示低浓度CS2接触可能是SCu和SZn含量降低的独立危险因素；干预组SCu和CZn含量均低于对照组（P＜0．05）。提示低浓度CS2接触引起SCn和Ssn含量的改变可能是不可逆的。 Taking CS2 workers aged over 10 years and under 45 years as spinning groups in a chemical fiber plant as the contact group, the same age and working-age range was selected for the same factory in the cotton pulp plant. CS2 was contacted but CS2 has now been stopped Thirty-three workers who had come into contact with more than 5 years as the intervention group and 23 workers who had never been exposed to CS2 served as the control group, conducted epidemiological cross-sectional survey to understand the effects of CS2 on workers’ serum copper and zinc. The results showed that the content of SCu and SZn in the exposure group was lower than that in the control group (P = 0.0001). The multivariate stepwise regression analysis controlled some confounding factors and further showed that the content of SCu and SZn had a certain relationship with CS2 exposure The correlation coefficients were -02374 and -02536 respectively), and CS2 all contributed negatively to the SCu and CSn contents (the partial regression coefficients β were -10.4173 and -8.4175, respectively). These results suggest that CS2 exposure at low concentration may be an independent risk factor for SCu and SZn reduction. The SCu and CZn concentrations in the intervention group were lower than those in the control group (P <0.05). It suggests that the changes of SCn and Ssn content caused by low concentration CS2 exposure may be irreversible.